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Aleglitazar
- Name Aleglitazar
- CAS 475479-34-6
- Purity 99%
Product Details
Quality Manufacturer Supply High Purity 99% Aleglitazar 475479-34-6 with Reasonable Price
- Molecular Formula: C24H23NO5S
- Molecular Weight: 437.516
- Vapor Pressure: 0mmHg at 25°C
- Melting Point: 146-147 °C
- Refractive Index: 1.627
- Boiling Point: 665.151 °C at 760 mmHg
- PKA: 3.54±0.46(Predicted)
- Flash Point: 356.071 °C
- PSA： 110.03000
- Density: 1.291 g/cm3
- LogP: 5.12830
Aleglitazar(Cas 475479-34-6) Usage
|
Use Description |
Aleglitazar is a pharmaceutical compound developed for its potential applications in the medical field, specifically in the treatment of cardiovascular diseases and diabetes. In the field of medicine, it has been studied for its role as a dual peroxisome proliferator-activated receptor (PPAR) agonist, which means it can simultaneously activate two types of PPAR receptors—PPAR-alpha and PPAR-gamma. This dual activation can have beneficial effects on lipid metabolism, insulin sensitivity, and glucose regulation, making it a candidate for the management of conditions like type 2 diabetes and dyslipidemia. However, it's important to note that as of my last knowledge update in September 2021, aleglitazar had faced challenges in clinical development due to safety concerns, particularly related to cardiovascular events. Therefore, its exact role and usage in the medical field were still under evaluation and required further research and regulatory approval. Please consult more recent sources for the latest information on aleglitazar's status and applications in the medical field. |
InChI:InChI=1/C24H23NO5S/c1-15-19(25-23(30-15)16-6-4-3-5-7-16)10-12-29-20-9-8-17(14-21(28-2)24(26)27)22-18(20)11-13-31-22/h3-9,11,13,21H,10,12,14H2,1-2H3,(H,26,27)/t21-/m0/s1
475479-34-6 Relevant articles
SOLID STATE FORMS OF ALEGLITAZAR SODIUM
-
Paragraph 0067; 0068, (2014/01/07)
The present invention provides solid sta...
PROCESS FOR THE PREPARATION OF PROPIONIC ACID DERIVATIVES
-
Page/Page column 25-26, (2011/06/26)
The invention relates to a process for t...
PROCESS FOR THE PREPARATION OF PROPIONIC ACID DERIVATIVES
-
Page/Page column 10, (2010/10/19)
The invention relates to a process for t...
Aleglitazar, a new, potent, and balanced dual PPARα/γ agonist for the treatment of type II diabetes
Benardeau, Agnes,Benz, Joerg,Binggeli, Alfred,Blum, Denise,Boehringer, Markus,Grether, Uwe,Hilpert, Hans,Kuhn, Bernd,Maerki, Hans Peter,Meyer, Markus,Puentener, Kurt,Raab, Susanne,Ruf, Armin,Schlatter, Daniel,Mohr, Peter
experimental part, p. 2468 - 2473 (2010/03/24)
Design, synthesis, and SAR of novel α-al...
475479-34-6 Process route
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![(Z)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-acrylic acid](/upload/2026/11/a98d3e1a37c740beb873eaa79294c869_82104429-338e-410c-8422-9755b7aba2a4.png)
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849150-55-6
(Z)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-acrylic acid
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![[14C]-Aleglitazar](/upload/2026/11/0edb36e7dd1547b1a5f679169ee64b16_ad8249b9-16d0-4f3b-8242-0a4c95e8eb19.png)
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475479-34-6
[14C]-Aleglitazar
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![(2R)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propionic acid](/upload/2026/11/9cca8777db624b94b6ca72e9f67f8f04_9793994c-8219-4ec6-8322-332a5f4a880a.png)
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849150-59-0
(2R)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propionic acid
Conditions
| Conditions | Yield |
|---|---|
|
With
sodium hydroxide; hydrogen;
Ru(OAc)2((S)-(6-MeO-2-naphthyl)-MeOBIPHEP);
In
methanol; dichloromethane; water;
at 40 ℃;
for 24h;
under 11251.1 Torr;
Product distribution / selectivity;
|
100%
|
|
With
(S)-1-phenyl-ethylamine; hydrogen;
BF4(1-)*C55H46F12FeNP2Ru(1+);
In
methanol; dichloromethane;
at 40 ℃;
for 16h;
under 22502.3 Torr;
Product distribution / selectivity;
|
58%
|
|
With
hydrogen; triethylamine;
chloro(1,5-cyclooctadiene)rhodium(I) dimer; (R,S)-BPPFA-EPIP;
In
tetrahydrofuran;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
67 % ee
|
|
With
hydrogen; triethylamine;
chloro(1,5-cyclooctadiene)rhodium(I) dimer; (R,S)-(2-Furyl)-PPFA-P(Cyp)2;
In
tetrahydrofuran;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
74 % ee
|
|
With
hydrogen; triethylamine;
Ru(OAc)2((S)-(6-MeO-2-naphthyl)-MeOBIPHEP);
In
toluene;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
70 % ee
|
|
With
hydrogen; triethylamine;
Ru(OAc)2((S)-(6-MeO-2-naphthyl)-MeOBIPHEP);
In
ethanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
73 % ee
|
|
With
hydrogen; triethylamine;
[Ru(OAc)2-((S)-BIPHEMP)];
In
toluene;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
64 % ee
|
|
With
hydrogen; triethylamine;
[Ru(OAc)2-((S)-BIPHEMP)];
In
ethanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
67 % ee
|
|
With
hydrogen; triethylamine;
C40H38O4P2RuS2;
In
toluene;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
68 % ee
|
|
With
hydrogen;
(S,S,S,S)-Me-f-KetalPhos; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate;
In
dichloromethane;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
33 % ee
|
|
With
hydrogen;
(S,S,S,S)-Me-f-KetalPhos; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate;
In
ethyl acetate;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
22 % ee
|
|
With
hydrogen;
(S,S,S,S)-Me-f-KetalPhos; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate;
In
methanol; toluene;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
49 % ee
|
|
With
hydrogen;
(S,S,S,S)-Me-f-KetalPhos; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate;
In
1,4-dioxane;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
36 % ee
|
|
With
hydrogen;
(S,S,S,S)-Me-f-KetalPhos; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate;
In
tetrahydrofuran; methanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
55 % ee
|
|
With
hydrogen;
(S,S,S,S)-Me-f-KetalPhos; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate;
In
methanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
47 % ee
|
|
With
hydrogen;
chloro(1,5-cyclooctadiene)rhodium(I) dimer; (R,S)-BPPFA-EPIP;
In
ethyl acetate;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
76 % ee
|
|
With
hydrogen;
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R,S)-PPCr-P(tBu)2;
In
dichloromethane;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
57 % ee
|
|
With
hydrogen;
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R,S)-PPCr-P(tBu)2;
In
ethyl acetate;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
56 % ee
|
|
With
hydrogen;
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R,S)-PPCr-P(tBu)2;
In
methanol; toluene;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
65 % ee
|
|
With
hydrogen;
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R,S)-PPCr-P(tBu)2;
In
1,4-dioxane;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
56 % ee
|
|
With
hydrogen;
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R,S)-PPCr-P(tBu)2;
In
tetrahydrofuran; methanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
62 % ee
|
|
With
hydrogen;
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R,S)-PPCr-P(tBu)2;
In
methanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
65 % ee
|
|
With
hydrogen;
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R,S)-BPPFA-EPIP;
In
dichloromethane;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
67 % ee
|
|
With
hydrogen;
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R,S)-BPPFA-EPIP;
In
toluene;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
70 % ee
|
|
With
hydrogen;
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R,S)-BPPFA-EPIP;
In
1,4-dioxane;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
67 % ee
|
|
With
hydrogen;
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R,S)-BPPFA-EPIP;
In
methanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
74 % ee
|
|
With
hydrogen;
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (S,R)-BPPFA-EDMA;
In
tetrahydrofuran; methanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
78 % ee
|
|
With
hydrogen;
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R,S)-(2-Furyl)-PPFA-P(Cyp)2;
In
ethyl acetate;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
16 % ee
|
|
With
hydrogen;
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R,S)-(2-Furyl)-PPFA-P(Cyp)2;
In
toluene;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
14 % ee
|
|
With
hydrogen;
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R,S)-(2-Furyl)-PPFA-P(Cyp)2;
In
1,4-dioxane;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
68 % ee
|
|
With
hydrogen;
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R,S)-(2-Furyl)-PPFA-P(Cyp)2;
In
tetrahydrofuran; methanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
77 % ee
|
|
With
hydrogen;
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R,S)-(2-Furyl)-PPFA-P(Cyp)2;
In
methanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
51 % ee
|
|
With
hydrogen;
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; 2,2',5,5'-tetramethyl-4,4'-bis(diphenylphosphino)-3,3'-bithienyl;
In
tetrahydrofuran; methanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
58 % ee
|
|
With
hydrogen;
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R)-(CH3OC6H3P(C6H2(C(CH3)3)2OCH3)2)2;
In
dichloromethane;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
42 % ee
|
|
With
hydrogen;
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R)-(CH3OC6H3P(C6H2(C(CH3)3)2OCH3)2)2;
In
ethyl acetate;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
56 % ee
|
|
With
hydrogen;
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R)-(CH3OC6H3P(C6H2(C(CH3)3)2OCH3)2)2;
In
toluene;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
57 % ee
|
|
With
hydrogen;
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R)-(CH3OC6H3P(C6H2(C(CH3)3)2OCH3)2)2;
In
1,4-dioxane;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
60 % ee
|
|
With
hydrogen;
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R)-(CH3OC6H3P(C6H2(C(CH3)3)2OCH3)2)2;
In
tetrahydrofuran; methanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
57 % ee
|
|
With
hydrogen;
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R)-(CH3OC6H3P(C6H2(C(CH3)3)2OCH3)2)2;
In
methanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
33 % ee
|
|
With
hydrogen;
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R,S)-(2-Furyl)-PPFA-P(Cy)2;
In
tetrahydrofuran; methanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
74 % ee
|
|
With
hydrogen;
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R)-(+)-2,2′-bis(di-2-furanylphosphino)-6,6′-dimethoxy-1,1′-biphenyl;
In
ethyl acetate;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
67 % ee
|
|
With
hydrogen;
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R)-(+)-2,2′-bis(di-2-furanylphosphino)-6,6′-dimethoxy-1,1′-biphenyl;
In
methanol; toluene;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
61 % ee
|
|
With
hydrogen;
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R)-(+)-2,2′-bis(di-2-furanylphosphino)-6,6′-dimethoxy-1,1′-biphenyl;
In
1,4-dioxane;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
70 % ee
|
|
With
hydrogen;
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R)-(+)-2,2′-bis(di-2-furanylphosphino)-6,6′-dimethoxy-1,1′-biphenyl;
In
tetrahydrofuran; methanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
74 % ee
|
|
With
hydrogen;
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R)-(+)-2,2′-bis(di-2-furanylphosphino)-6,6′-dimethoxy-1,1′-biphenyl;
In
methanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
64 % ee
|
|
With
hydrogen;
Ru(OAc)2((S)-(6-MeO-2-naphthyl)-MeOBIPHEP);
In
dichloromethane;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
61 % ee
|
|
With
hydrogen;
Ru(OAc)2((S)-(6-MeO-2-naphthyl)-MeOBIPHEP);
In
ethyl acetate;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
67 % ee
|
|
With
hydrogen;
Ru(OAc)2((S)-(6-MeO-2-naphthyl)-MeOBIPHEP);
In
toluene;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
71 % ee
|
|
With
hydrogen;
Ru(OAc)2((S)-(6-MeO-2-naphthyl)-MeOBIPHEP);
In
ethanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
71 - 73 % ee
|
|
With
hydrogen;
Ru(OAc)2((S)-(6-MeO-2-naphthyl)-MeOBIPHEP);
In
tetrahydrofuran;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
62 % ee
|
|
With
hydrogen;
C44H40O4P2Ru;
In
ethanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
63 % ee
|
|
With
hydrogen;
[Ru(OAc)2((R)-MeOBIPHEP)];
In
ethanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
56 % ee
|
|
With
hydrogen;
C58H46O6P2Ru;
In
ethanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
68 % ee
|
|
With
hydrogen;
C46H46O10P2Ru;
In
dichloromethane;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
63 % ee
|
|
With
hydrogen;
C46H46O10P2Ru;
In
ethyl acetate;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
66 % ee
|
|
With
hydrogen;
C46H46O10P2Ru;
In
toluene;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
61 % ee
|
|
With
hydrogen;
C46H46O10P2Ru;
In
ethanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
69 % ee
|
|
With
hydrogen;
C46H46O10P2Ru;
In
tetrahydrofuran;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
62 % ee
|
|
With
hydrogen;
[Ru(OAc)2-((S)-BIPHEMP)];
In
dichloromethane;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
61 % ee
|
|
With
hydrogen;
[Ru(OAc)2-((S)-BIPHEMP)];
In
ethyl acetate;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
60 % ee
|
|
With
hydrogen;
[Ru(OAc)2-((S)-BIPHEMP)];
In
toluene;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
78 % ee
|
|
With
hydrogen;
[Ru(OAc)2-((S)-BIPHEMP)];
In
ethanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
68 % ee
|
|
With
hydrogen;
[Ru(OAc)2-((S)-BIPHEMP)];
In
tetrahydrofuran;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
60 % ee
|
|
With
hydrogen;
C54H46O6P2Ru;
In
dichloromethane;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
53 % ee
|
|
With
hydrogen;
C54H46O6P2Ru;
In
ethyl acetate;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
54 % ee
|
|
With
hydrogen;
C54H46O6P2Ru;
In
toluene;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
56 % ee
|
|
With
hydrogen;
C54H46O6P2Ru;
In
ethanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
64 % ee
|
|
With
hydrogen;
C54H46O6P2Ru;
In
tetrahydrofuran;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
52 % ee
|
|
With
hydrogen;
C54H42O8P2Ru;
In
ethanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
64 % ee
|
|
With
hydrogen;
C46H46O4P2Ru;
In
dichloromethane;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
65 % ee
|
|
With
hydrogen;
C46H46O4P2Ru;
In
ethyl acetate;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
64 % ee
|
|
With
hydrogen;
C46H46O4P2Ru;
In
toluene;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
73 % ee
|
|
With
hydrogen;
C46H46O4P2Ru;
In
ethanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
62 % ee
|
|
With
hydrogen;
C46H46O4P2Ru;
In
tetrahydrofuran;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
66 % ee
|
|
With
hydrogen;
[Ru(OAc)2-((S)-MeOBIPHEP)];
In
ethanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
61 % ee
|
|
With
hydrogen;
C50H50O8P2Ru;
In
ethanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
59 % ee
|
|
With
hydrogen;
C46H46O6P2Ru;
In
ethanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
58 % ee
|
|
With
hydrogen;
C66H54O6P2Ru;
In
ethanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
55 % ee
|
|
With
hydrogen;
C56H56FeN2O4P2Ru;
In
ethanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
55 % ee
|
|
With
hydrogen;
C46H46O10P2Ru;
In
ethanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
54 % ee
|
|
With
hydrogen;
C50H54O6P2Ru;
In
ethanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
53 % ee
|
|
With
hydrogen;
C46H46O6P2Ru;
In
ethanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
52 % ee
|
|
With
hydrogen;
C50H54O4P2Ru;
In
ethanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
51 % ee
|
|
With
hydrogen;
Ru(S-BINAP)(OAc)2;
In
ethanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
51 % ee
|
|
With
hydrogen;
C34H30O6P2RuS4;
In
ethanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
42 % ee
|
|
With
hydrogen;
C40H38O4P2RuS2;
In
ethyl acetate;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
76 % ee
|
|
With
hydrogen;
C40H38O4P2RuS2;
In
toluene;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
66 % ee
|
|
With
hydrogen;
C40H38O4P2RuS2;
In
tetrahydrofuran;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
73 % ee
|
|
With
sodium hydroxide; hydrogen;
Ru(OAc)2((S)-(6-MeO-2-naphthyl)-MeOBIPHEP);
In
methanol; dichloromethane; water;
at 40 ℃;
for 4h;
under 45004.5 Torr;
Product distribution / selectivity;
|
71.5 % ee
|
|
With
sodium hydroxide; hydrogen;
[Ru(OAc)2-((S)-BIPHEMP)];
In
methanol; dichloromethane; water;
at 40 ℃;
for 4h;
under 45004.5 Torr;
Product distribution / selectivity;
|
67.9 % ee
|
|
With
sodium hydroxide; hydrogen;
[Ru(OAc)2-((S)-MeOBIPHEP)];
In
methanol; dichloromethane; water;
at 40 ℃;
for 4h;
under 45004.5 Torr;
Product distribution / selectivity;
|
62.9 % ee
|
|
With
sodium hydroxide; hydrogen;
[Ru(TFA)2((S)-BIPHEMP)];
In
methanol; dichloromethane; water;
at 40 ℃;
for 4h;
under 45004.5 Torr;
Product distribution / selectivity;
|
67.7 % ee
|
|
With
sodium hydroxide; hydrogen;
[Ru(TFA)2-((S)-MeOBIPHEP)];
In
methanol; dichloromethane; water;
at 40 ℃;
for 4h;
under 45004.5 Torr;
Product distribution / selectivity;
|
63.6 % ee
|
|
With
sodium hydroxide; hydrogen;
[Ru(TFA)2-((S)-TriMeOBIPHEP)];
In
methanol; dichloromethane; water;
at 40 ℃;
for 4h;
under 45004.5 Torr;
Product distribution / selectivity;
|
71.4 % ee
|
|
With
(S)-1-phenyl-ethylamine; hydrogen;
BF4(1-)*C2H3N*C5H7(1-)*C52H50FeN2P2*Ru(2+);
In
methanol; dichloromethane;
at 40 ℃;
for 16h;
under 22502.3 Torr;
Product distribution / selectivity;
|
69 % ee
|
|
With
Ru(OCOCH3)2{(S)-2,2'-bis(diphenylphosphino)-1,1'-dinaphthyl)}; hydrogen; sodium hydroxide;
In
methanol; dichloromethane;
at 80 ℃;
for 16h;
under 30003 Torr;
Overall yield = 7.52 g;
Autoclave;
|
50 % ee
|
-
-
849150-55-6
(Z)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-acrylic acid
-
-
475479-34-6
[14C]-Aleglitazar
Conditions
| Conditions | Yield |
|---|---|
|
With
hydrogen;
[Ir((S,S)-DBT-Bn-SIPHOX)(COD)]BARF; (S)-1-phenyl-ethylamine;
In
tetrahydrofuran; methanol;
at 60 - 80 ℃;
for 10h;
under 22502.3 Torr;
Product distribution / selectivity;
|
70%
|
|
With
(S)-1-phenyl-ethylamine; hydrogen;
[Ir((S,S)-7-[4,5-dihydro-4-benzyloxazol-2-yl]-7'-di(3,5-di-tert-butylphenyl)phosphino-1,1'-spirobiindane)(1,5-cyclooctadiene)][tetrakis[3,5-bis(trifluoromethyl)phenyl]borate];
In
tetrahydrofuran; methanol;
at 60 - 80 ℃;
for 10h;
under 22502.3 Torr;
Product distribution / selectivity;
Sealed autoclave;
|
70%
|
|
With
sodium hydroxide; hydrogen;
[Ru(OAc)2((S)-TMBTP)];
In
methanol; dichloromethane; water;
at 40 ℃;
for 6h;
under 22502.3 Torr;
Product distribution / selectivity;
|
86 - 99.6 % ee
|
|
With
hydrogen; triethylamine;
[Ru(OAc)2((S)-TMBTP)];
In
methanol; dichloromethane;
at 40 ℃;
for 6 - 23.5h;
under 45004.5 Torr;
Product distribution / selectivity;
|
91.3 - 92.0 % ee
|
|
With
hydrogen; triethylamine;
[Ru(OAc)2((S)-TMBTP)];
In
ethanol;
at 60 ℃;
for 6h;
under 45004.5 Torr;
Product distribution / selectivity;
|
85 % ee
|
|
With
hydrogen;
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R,S)-BPPFA-EPIP;
In
tetrahydrofuran; methanol;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
80 % ee
|
|
With
hydrogen;
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R)-(+)-2,2′-bis(di-2-furanylphosphino)-6,6′-dimethoxy-1,1′-biphenyl;
In
dichloromethane;
at 60 ℃;
for 3h;
under 45004.5 Torr;
Product distribution / selectivity;
|
84 % ee
|
|
With
hydrogen;
[Ru(OAc)2((S)-TMBTP)];
In
ethanol;
at 60 ℃;
for 3 - 6h;
under 45004.5 Torr;
Product distribution / selectivity;
|
89 - 90 % ee
|
|
With
hydrogen; sodium methylate;
[Ru(OAc)2((S)-TMBTP)];
In
methanol; dichloromethane;
at 20 ℃;
for 6h;
under 45004.5 Torr;
Product distribution / selectivity;
|
92 - 93 % ee
|
|
With
hydrogen; sodium methylate;
[Ru(OAc)2((S)-TMBTP)];
In
methanol; dichloromethane;
at 20 - 40 ℃;
for 6 - 23.5h;
under 45004.5 Torr;
Product distribution / selectivity;
|
90.3 - 93.7 % ee
|
|
With
hydrogen; sodium methylate;
[Ru(OAc)2((S)-TMBTP)];
In
methanol; ethanol;
at 20 ℃;
for 26 - 26.5h;
under 22502.3 - 45004.5 Torr;
Product distribution / selectivity;
|
93.0 - 93.6 % ee
|
|
With
hydrogen; sodium methylate;
[Ru(OAc)2((S)-TMBTP)];
In
ethanol;
at 20 - 60 ℃;
for 6h;
under 22502.3 - 45004.5 Torr;
Product distribution / selectivity;
|
89 - 93 % ee
|
|
With
(S)-1-phenyl-ethylamine; hydrogen;
[Ru(OAc)2((S)-TMBTP)];
In
methanol; dichloromethane; water;
at 40 - 60 ℃;
for 6h;
under 22502.3 Torr;
Product distribution / selectivity;
|
91.2 - 92.2 % ee
|
|
With
potassium hydroxide; hydrogen;
[Ru(OAc)2((S)-TMBTP)];
In
methanol; dichloromethane; water;
at 40 ℃;
for 5h;
under 45004.5 Torr;
Product distribution / selectivity;
|
92.0 % ee
|
|
With
disodium hydrogenphosphate; hydrogen;
[Ru(OAc)2((S)-TMBTP)];
In
methanol; dichloromethane; water;
at 40 ℃;
for 5h;
under 45004.5 Torr;
Product distribution / selectivity;
|
91.5 % ee
|
|
With
sodium hydroxide; hydrogen;
[Ru(TFA)2((S)-TMBTP)];
In
methanol; dichloromethane; water;
at 40 ℃;
for 9h;
under 45004.5 Torr;
Product distribution / selectivity;
|
91.1 % ee
|
|
With
sodium hydroxide; hydrogen;
[Ru(OAc)2((S)-TMBTP)];
In
methanol; dichloromethane; water;
at 20 - 40 ℃;
for 6 - 24h;
under 3750.38 - 45004.5 Torr;
Product distribution / selectivity;
|
90.1 - 94.1 % ee
|
475479-34-6 Upstream products
-
849150-55-6
(Z)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-acrylic acid
-
475480-89-8
(S)-4-benzyl-3-((S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propionyl)-oxazolidin-2-one
-
475479-24-4
2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propionic acid
475479-34-6 Downstream products
-
849150-56-7
(S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propionic acid (S)-phenyl ethylamine salt
-
881663-41-8
(S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propionic acid L-norephedrine salt
-
1578246-97-5
diisopropylammonium (S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propanoate
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