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Mafosfamide

  • Name Mafosfamide
  • CAS 88859-04-5
  • Purity 99%
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Product Details

Chemical plants supply high-quality Mafosfamide 88859-04-5 in bulk

  • Molecular Formula: C9H19Cl2N2O5PS2
  • Molecular Weight: 401.272
  • Refractive Index: 1.573 
  • PSA： 139.43000 
  • Density: 1.54 g/cm3 
  • LogP: 3.24070 

Mafosfamide(Cas 88859-04-5) Usage

General Description

Mafosfamide is a prodrug of the alkylating chemotherapeutic agent ifosfamide, which is used to treat various types of cancer. It is converted into ifosfamide in the body and exerts its cytotoxic effects by alkylating DNA and inhibiting cell division. Mafosfamide is particularly effective against cancers of the bladder, breast, lung, and soft tissue sarcomas. It is often used in combination with other chemotherapy drugs to enhance its antitumor activity. Despite its effectiveness, mafosfamide can cause side effects such as nausea, vomiting, and myelosuppression, and it should be administered under the supervision of a healthcare professional.

InChI:InChI=1/C9H19Cl2N2O5PS2/c10-2-4-13(5-3-11)19(14)12-9(1-6-18-19)20-7-8-21(15,16)17/h9H,1-8H2,(H,12,14)(H,15,16,17)

88859-04-5 Relevant articles

Activation Mechanisms of Mafosfamide and the Role of Thiols in Cyclophosphamide Metabolism

Kwon, Chul-Hoon,Borch, Richard F.,Engel, Jurgen,Niemeyer, Ulf

, p. 395 - 399 (2007/10/02)

cis-Mafosfamide (cis-5) (ASTA Z7557), a ...

Oxazaphosphorin-4-thio-alkanesulphonic acids, and neutral salts thereof

-

, (2008/06/13)

This invention relates to new oxazaphosp...

88859-04-5 Process route

cis-Mosfosfamide
84210-72-0,88859-04-5

cis-Mosfosfamide

aldophosphamide
35144-64-0

aldophosphamide

aldophosphamide hydrate
88685-78-3

aldophosphamide hydrate

cis-4-hydroxycyclophosphamide
61903-29-5,88852-77-1,40277-05-2,61903-30-8,88852-78-2

cis-4-hydroxycyclophosphamide

trans-4-hydroxycyclophosphamide
61903-30-8,88852-78-2,40277-05-2,61903-29-5,88852-77-1

trans-4-hydroxycyclophosphamide

C<sub>9</sub>H<sub>21</sub>Cl<sub>2</sub>N<sub>2</sub>O<sub>6</sub>PS<sub>2</sub>
105639-84-7

C9 H21 Cl2 N2 O6 PS2

2-{(2S,4S)-2-[Bis-(2-chloro-ethyl)-amino]-2-oxo-2λ<sup>5</sup>-[1,3,2]oxazaphosphinan-4-ylsulfanyl}-ethanesulfonic acid
92745-18-1,88859-04-5

2-{(2S,4S)-2-[Bis-(2-chloro-ethyl)-amino]-2-oxo-2λ5 -[1,3,2]oxazaphosphinan-4-ylsulfanyl}-ethanesulfonic acid

Conditions
Conditions Yield
With acetate bufer; In water; at 37 ℃; Rate constant; Mechanism; var. buffer conc., var. pH, var. ionic strength;
mesna
19767-45-4

mesna

cis-4-hydroxycyclophosphamide
61903-29-5,88852-77-1,40277-05-2,61903-30-8,88852-78-2

cis-4-hydroxycyclophosphamide

aldophosphamide
35144-64-0

aldophosphamide

trans-4-hydroperoxycyclophosphamide
39800-16-3,56922-83-9,61903-31-9,62435-42-1,146566-40-7

trans-4-hydroperoxycyclophosphamide

aldophosphamide hydrate
88685-78-3

aldophosphamide hydrate

C<sub>9</sub>H<sub>21</sub>Cl<sub>2</sub>N<sub>2</sub>O<sub>6</sub>PS<sub>2</sub>
105639-84-7

C9 H21 Cl2 N2 O6 PS2

cis-Mosfosfamide
84210-72-0,88859-04-5

cis-Mosfosfamide

2-{(2S,4S)-2-[Bis-(2-chloro-ethyl)-amino]-2-oxo-2λ<sup>5</sup>-[1,3,2]oxazaphosphinan-4-ylsulfanyl}-ethanesulfonic acid
92745-18-1,88859-04-5

2-{(2S,4S)-2-[Bis-(2-chloro-ethyl)-amino]-2-oxo-2λ5 -[1,3,2]oxazaphosphinan-4-ylsulfanyl}-ethanesulfonic acid

Conditions
Conditions Yield
With acetate buffer; In water; at 37 ℃;

88859-04-5 Upstream products

  • 19767-45-4
    19767-45-4

    mesna

  • 61903-29-5
    61903-29-5

    cis-4-hydroxycyclophosphamide

  • 84210-72-0
    84210-72-0

    cis-Mosfosfamide

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