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INCB8761(PF-4136309)
- Name INCB8761(PF-4136309)
- CAS 1341224-83-6
- Purity 99%
Product Details
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1.What is the INCB8761(PF-4136309) ?
PF 4136309 is a CCR5 receptor antagonists that contributes to the treatment of rheumatoid arthritis.
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624-28-2
2,5-dibromopyridine
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1341224-83-6
PF-4136309
| Conditions | Yield |
|---|---|
|
Multi-step reaction
with
4
steps
1.1: n-butyllithium / toluene / 2.5 h / -78 °C
1.2: -78 - 20 °C
2.1: isopropylmagnesium chloride / tetrahydrofuran / 3.67 h / 25 °C / Inert atmosphere
2.2: 25 °C / Inert atmosphere
3.1: hydrogenchloride / tetrahydrofuran; water / 1 h / 20 - 25 °C
4.1: triethylamine / 2-methyl-propan-1-ol / 0.5 h / Cooling with ice
4.2: 4 h / 20 °C
With
hydrogenchloride; n-butyllithium; isopropylmagnesium chloride; triethylamine;
In
tetrahydrofuran; 2-methyl-propan-1-ol; water; toluene;
|
-
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4746-97-8
cyclohexanedione monoethylene ketal
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1341224-83-6
PF-4136309
| Conditions | Yield |
|---|---|
|
Multi-step reaction
with
4
steps
1.1: n-butyllithium / toluene / 2.5 h / -78 °C
1.2: -78 - 20 °C
2.1: isopropylmagnesium chloride / tetrahydrofuran / 3.67 h / 25 °C / Inert atmosphere
2.2: 25 °C / Inert atmosphere
3.1: hydrogenchloride / tetrahydrofuran; water / 1 h / 20 - 25 °C
4.1: triethylamine / 2-methyl-propan-1-ol / 0.5 h / Cooling with ice
4.2: 4 h / 20 °C
With
hydrogenchloride; n-butyllithium; isopropylmagnesium chloride; triethylamine;
In
tetrahydrofuran; 2-methyl-propan-1-ol; water; toluene;
|
2.What is the CAS number for INCB8761(PF-4136309) ?
The CAS number of INCB8761(PF-4136309) is 1341224-83-6.
More information of INCB8761(PF-4136309) 1341224-83-6 are:
|
CAS?Number |
1341224-83-6 |
|
Density |
1.40±0.1 g/cm3(Predicted) |
|
Boiling Point |
712.2±60.0 °C(Predicted) |
|
HS CODE |
2933998090 |
|
PSA |
120.34000 |
|
LogP |
4.02780 |
|
Pka |
13.17±0.46(Predicted) |
3.What are another words for INCB8761(PF-4136309) ?
Synonyms?for?INCB8761(PF-4136309) 1341224-83-6:INCB 8761(PF-4136309);(S)-N-(2-(3-((4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide;(S)-N-[2-(3-{trans-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexylamino}pyrrolidin-1-yl)-2-oxoethyl]-3-(trifluoromethyl)benzamide;INCB8761(PF-4136309);
4.What is the molecular formula of INCB8761(PF-4136309)?
The chemical formula of ?INCB8761(PF-4136309) is?C29H31F3N6O3 which containing 29 Carbon atoms,31 Hydrogen atoms,3 Fluorine atoms,6 Nitrogen atoms and 3 Oxygen atoms,and the molecular weight of??INCB8761(PF-4136309)?is 568.599.
5.What is INCB8761(PF-4136309) (1341224-83-6) used for?
PF-4136309 is a chemokine (C-C motif) receptor 2 (CCR2) antagonist (IC50s = 5.2, 13, and 17 nM for the human, rat, and mouse receptors, respectively). It also inhibits the voltage-gated potassium channel subtype Kv11.1 by 35% when used at a concentration of 10 μM. PF-4136309 decreases isolated human monocyte chemotaxis induced by chemokine (C-C motif) ligand 2 (CCL2) with an IC50 value of 3.9 nM.
Relevant articles related to INCB8761(PF-4136309):
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Article |
Source |
6.Buy INCB8761(PF-4136309) with the best price .
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